70024-40-7
- Product Name：Terazosin hydrochloride dihydrate
- Molecular Formula：C19H25N5O4.HCl.2(H2O)
- Purity：99%
- Molecular Weight：441.915
Product Details
pd_meltingpoint:271-274 °C
Appearance:white or off-white crystalline powder
Factory Supply industrial standard Terazosin hydrochloride dihydrate 70024-40-7 In Stock
- Molecular Formula:C19H25N5O4*ClH*H2O
- Molecular Weight:441.915
- Appearance/Colour:white or off-white crystalline powder
- Vapor Pressure:1.59E-17mmHg at 25°C
- Melting Point:271-274 °C
- Boiling Point:664.5 °C at 760 mmHg
- Flash Point:355.7 °C
- PSA：121.50000
- LogP:2.31430
Terazosin hydrochloride dihydrate(Cas 70024-40-7) Usage
|
Manufacturing Process |
To a solution of n-butanol (316 ml), water (24 ml) and N-(2- tetrahydrofuroyl)piperazine (20 g) were added, while stirring, 4-amino-2- chloro-6,7-dimethoxyquinazoline (22.2 g). The reaction mixture was heated to reflux and the reflux was maintained for about 9 h. Then the reaction mixture was cooled to room temperature and stirred at this temperature for about 10- 12 h. The crystals were collected by filtration, washed with n-BuOH and dried in vacuo at 40-50°C to yield 40.1 g (94%) of the 1-(4-amino-6,7-dimethoxy- 2-quinazolinyl)-4-(tetrahydrofuroyl)piperazine hydrochloride dihydrate |
|
Therapeutic Function |
Antihypertensive |
InChI:InChI=1/C19H25N5O4.ClH.2H2O/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;;;/h10-11,14H,3-9H2,1-2H3,(H2,20,21,22);1H;2*1H2
70024-40-7 Relevant articles
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-
, (2008/06/13)
A process for the preparation of 1-(4-am...
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-
, (2008/06/13)
The present invention relates to the dis...
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-
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70024-40-7 Process route
-
- 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine
-
- 63074-07-7
N-(tetrahydro-2-furoyl)-piperazine
-
![1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)-carbonyl]piperazine monohydrochloride dihydrate](/upload/2024/7/621672db-0c5e-4b87-9314-9673c22cacd1.png)
- 70024-40-7
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)-carbonyl]piperazine monohydrochloride dihydrate
| Conditions | Yield |
|---|---|
|
In 1,4-dioxane; water;
|
|
|
In ethanol; water;
|
36.44 g (85.5%) |
|
In 2-methyl-propan-1-ol; water;
|
39.2 g (91.9%) |
|
In water; cyclohexanol;
|
-
- 67-63-0,8013-70-5
isopropyl alcohol
-
- 23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine
-
- 63074-07-7
N-(tetrahydro-2-furoyl)-piperazine
-
- 70024-40-7
1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)-carbonyl]piperazine monohydrochloride dihydrate
| Conditions | Yield |
|---|---|
|
In water;
|
38.8 g (94%) |
70024-40-7 Upstream products
-
67-63-0
isopropyl alcohol
-
23680-84-4
2-chloro-6,7-dimethoxyquinazolin-4-amine
-
63074-07-7
N-(tetrahydro-2-furoyl)-piperazine
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